Understanding the role of the protein PAX3 in cancer development

Paired Box 3 (PAX3) is a protein that plays a critical role in the formation of tissues and organs during embryonic development and can positively (and less frequently, negatively) regulate gene expression. While progress has been made to advance our understanding of this critical and multi-faceted protein, there is still much that is unknown about the mechanisms by which PAX3 controls such a wide array of key cellular functions.