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  "path": "/news/2026-03-cellular-stress-immune-exhaustion-weaken.html",
  "publishedAt": "2026-03-18T12:00:05.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "Cancer-fighting T cells do not simply \"run out of energy.\" They are molecularly reprogrammed. For years, mitochondrial dysfunction has been recognized as a hallmark of exhausted T cells in tumors. Yet how metabolic stress translates into stable transcriptional reprogramming remained unclear.",
  "title": "Cellular stress signal found to drive immune exhaustion and weaken cancer therapy"
}