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  "path": "/news/2026-03-obesity-liver-cancer-aggressive-resistant.html",
  "publishedAt": "2026-03-18T09:10:02.000Z",
  "site": "https://medicalxpress.com",
  "textContent": "A research team affiliated with UNIST has made a significant discovery explaining why liver cancers associated with obesity and metabolic disorders tend to be more aggressive and less responsive to conventional treatments. The study reveals that a specific signaling pathway involving endotrophin—a protein secreted during liver fibrosis—and the receptor protein CD44 promotes tumor malignancy and drug resistance.",
  "title": "New study identifies how obesity-related liver cancer becomes more aggressive and resistant to treatment"
}