FDA-approved cancer drug fedratinib reshapes how cell organelles communicate, providing new therapeutic avenues

Cells behave like cities and organelles carry out infrastructural roles: mitochondria are powerhouses, the endoplasmic reticulum serves as a transport hub and lysosomes help with waste disposal. Communication between different parts of a cell is important for metabolism. This inter-organelle communication can occur at sites where these parts are in contact with each other, known as membrane contact sites.