New tracking tool reveals how T cells adapt in different organs

Our immune system relies on T cells to fight infections. But T cells don't just show up and react—first, they train, get a game plan, and coordinate their defenses in lymphoid organs. Researchers have struggled to understand how this counteroffensive evolves across these sites. Now, a new tool from researchers at The Rockefeller University and Biohub allows scientists to permanently tag recently activated T cells with a fluorescent protein to track how they travel and change during an infection.