Engineered immune cells show promise against brain metastases in preclinical study

A new study by researchers at Wake Forest University School of Medicine has identified a promising strategy to treat brain metastases, one of the most challenging and deadly complications of lung cancer. The research team developed a highly specialized type of immune cell, called a CAR macrophage, or CARMA, designed to find and attack tumor cells that spread to the brain. These engineered macrophages were able to enter the brain, seek out cancer cells, and slow tumor growth in preclinical models.