What HSV-1 does inside the nucleus, and why it may aid early diagnosis

Researchers at the University of Jyväskylä (Finland), in cooperation with national and international research groups, have shown that DNA viruses infect cells and take over the host cell nucleus, inducing dramatic structural modifications. Herpes simplex virus 1 (HSV-1) infection and the emergence of enlarged nuclear low-density viral replication compartments lead to changes in nuclear volume, chromatin organization, and the structure of nuclear lamina.