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  "path": "/health/weight-loss-jab-pill-eli-lilly-maintain-results",
  "publishedAt": "2026-05-12T22:00:02.000Z",
  "site": "https://www.gbnews.com",
  "tags": [
    "Child obesity crisis deepens as NHS treats children as young as four - 'Wake-up call!'",
    "'Slower ageing': Enjoying the arts linked to being a year younger biologically",
    "Sick note Britain: More than 10 million signed off work as absence crisis grips UK",
    "The GB News Editorial Charter"
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  "textContent": "\n\n\nPatients who have achieved weight loss through injectable medications such as Wegovy and Mounjaro may be able to preserve their results by transitioning to a daily tablet, according to new research published in Nature Medicine.\n\nThe study suggests that orforglipron, manufactured by Eli Lilly, could offer an \"effective approach\" for individuals seeking to maintain their slimmer figures without remaining on injections indefinitely.\n\n###\n\n\n\n\nLike its injectable counterparts, orforglipron belongs to the GLP-1 agonist class of drugs, which function by reducing appetite, slowing digestion and lowering blood sugar levels.\n\nThe medication received approval from the US Food and Drug Administration last month, though it remains unlicensed in Britain.\n\n###\n\n\n\n\nTRENDING\n\nStories\n\nVideos\n\nYour Say\n\n###\n\n\n\n\nThe trial enrolled 376 participants across the United States who had previously undergone treatment with either tirzepatide or semaglutide for 72 weeks.\n\nThese individuals were then randomly assigned to receive either orforglipron or a placebo daily for twelve months.\n\nThe results proved striking for those who had been taking tirzepatide, with orforglipron users retaining 74.7 per cent of their weight reduction compared to just 49.2 per cent among those given the placebo.\n\nFormer semaglutide patients fared even better, with 79.3 per cent maintaining their weight loss versus 37.6 per cent in the placebo group.\n\n###\n\n\n\n\n###\n\n\n\n\nEarlier research has demonstrated that individuals using weight loss injections typically regain weight after stopping treatment.\n\nDr Marie Spreckley, research programme manager at the University of Cambridge, praised the practical relevance of the findings.\n\n### LATEST DEVELOPMENTS:\n\n\n\n\n  * Child obesity crisis deepens as NHS treats children as young as four - 'Wake-up call!'\n  * 'Slower ageing': Enjoying the arts linked to being a year younger biologically\n  * Sick note Britain: More than 10 million signed off work as absence crisis grips UK\n\n\n\n###\n\n\n\n\n\"One of the most valuable aspects of this study is that it reflects a highly realistic clinical scenario,\" she said.\n\n\"Many people do not want to remain on injectable therapy indefinitely due to treatment burden, convenience, travel, storage requirements, cost, or personal preference.\"\n\n###\n\n\n\n\n###\n\n\n\n\n###\n\n\n\n\nDr Spreckley noted that the option to switch to an oral treatment whilst keeping much of the weight off \"could therefore represent an important additional option within longer-term obesity care pathways\".\n\nDr Simon Cork, senior lecturer in physiology at Anglia Ruskin University, emphasised the financial considerations surrounding these treatments.\n\n\"This limits their long-term applicability both for private purchasers and the NHS,\" he observed, noting that injectable medications, whilst more effective for weight loss, carry substantial costs.\n\n###\n\n\n\n\nHe explained that oral alternatives are considerably less expensive to produce, even if they do not achieve quite the same results as injections.\n\nDr Cork acknowledged that further investigation involving larger patient cohorts would be necessary, but suggested the research indicates \"a potential future for how patients with obesity are treated, and how the success of weight loss can be maintained\".\n\n\n\n\n\n\n\n**Our Standards: The GB News Editorial Charter**",
  "title": "Weight loss pill may offer 'effective approach' to maintaining results achieved through jabs"
}