Pneumatic delivery system and methods for use

A pneumatic delivery system is used to facilitate delivery of canisters comprising delivery payloads by unmanned systems, such as unmanned aerial vehicles (UAVs). The pneumatic delivery system comprises a tube having a channel within a tube wall, where a canister is configured to move through the tube. The tube comprises a tube opening and a transfer mechanism proximate the tube opening. The transfer mechanism engages a canister having a payload that is moved within the tube. The transfer mechanism moves the canister through the tube opening by extending from a first transfer position to a second transfer position. At the second transfer position, the transfer mechanism orients the tube and releases it to a UAV for delivery.