Encrypted dns, rethink dns

If i exclude the app from rethink dns it use the isp dns, my goal is using rethink dns with wireguard on and some apps exclude from wireguard. Is it possible that using rethink dns while wireguard on and some apps exclude from wireguard but using encrypted dns without private dns on? Example i excluded brave browser but i still need to input secure dns. I want to excluded the app and set encrypted dns without going to put secure dns in the browser setting. I hope i made it clear