Best Way To Add Additional HDD/SSD Ports To MB?

Current build MB only has four SATA ports and I was wondering what is the best way of adding the, at least two, additional ports I think I need? I thought just get a PCIe SATA card many of which are dual purpose SATA/eSATA. I've actually bought one for a previous build but never used it. But this time I did some more research on this subject, which I still know little about, and that suggests they're not the best/trouble free solution? So the obvious question: apart from getting a MB with more SATA ports, what is that best/trouble free solution?