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  "path": "/articles/d41586-026-01899-6",
  "publishedAt": "2026-06-25T23:49:34.688Z",
  "site": "https://www.nature.com",
  "tags": [
    "doi:10.1038/d41586-026-01899-6"
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  "textContent": "Nature, Published online: 25 June 2026; doi:10.1038/d41586-026-01899-6\n\nCholesterol carried by low-density lipoprotein (LDL) drives heart disease and is cleared by liver cells expressing the receptor LDLR. A cell-signalling mechanism has been discovered through which high cholesterol promotes the enzyme-mediated degradation of LDLR. Blocking this enzyme restores LDLR levels in liver cells, suggesting a new strategy for treating high cholesterol.",
  "title": "How long-term dietary cholesterol can slow down its own clearance by liver cells",
  "updatedAt": "2026-06-25T00:00:00.000Z"
}