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  "path": "/articles/s41586-026-10226-y",
  "publishedAt": "2026-03-19T07:30:55.260Z",
  "site": "https://www.nature.com",
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  "textContent": "Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10226-y\n\nThe excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which disrupts gene expression and results in projection patterns resembling those of non-mammalian brains.",
  "title": "Adaptive evolution of gene regulatory networks in mammalian neocortex",
  "updatedAt": "2026-03-18T00:00:00.000Z"
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