Multidimensional profiling of heterogeneity in supratentorial ependymomas

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10214-2 Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation.