Lipid metabolism drives dietary effects on T cell ferroptosis and immunity

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10193-4 The susceptibility of mouse and human T cells to ferroptosis is determined by the balance of systemic polyunsaturated and monounsaturated fatty acids, highlighting a key role for lipid metabolism and dietary composition in regulating T cell function.